The Ucar Lab at Jackson Laboratory for Genomic Medicine studies the dynamics of epigenomic regulation of gene expression in human cells and discovers predictive signatures pertaining to human aging and aging-diseases. We aim to uncover intricate regulatory programs in human cells and disruptions to these in pathologies by developing computational tools and pipelines.we study epigenomic remodeling in human cells associated with aging or pathologies by developing computational tools to integrate and interpret diverse epigenomic data.
Our current focus is to understand the regulatory programs disrupted with aging in human and mice immune cells and with type 2 diabetes (T2D) in human pancreatic islet cells. We place priority on making our tools user-friendly and publicly available to empower future discoveries. Our software can also be found at our GitHub page.